Nutritional values, bioactive compounds, and biological activities of some edible indigenous plants from Thailand: A review
Main Article Content
Keywords
bioactive compounds, biological activity, edible indigenous plants, local foods, nutrition
Abstract
Thai edible indigenous vegetables are used as traditional food and folklore medicines. This review aims to integrate consumption culture and functional health impact of eight edible plants, that are, Gnetum gnemon var. tenerum, Gymnema inodorum (Lour) Decne, Albizia lebbeck (L.) Benth, Melientha suavis Pierre, Sauropus androgynus, Glochidion wallichianum, Piper sarmentosum Roxb, and Basella alba L., which are commonly consumed by local Thai people. Reviews of all eight mentioned plants demonstrated essential pharmacological activity, including antioxidant activity, and health functions, such as antidiabetic, anti-obesity, antihypertensive, antimicrobial, anticancer, and anti-inflammatory usage; they also help prevent neurotransmitters from degrading. However, comprehensive animal tests and clinical trials are needed to further clarify the results to increase utilization and safety as well as commercialization of these plants.
References
Akmal M.N., Aziz I.A., and Azlina M.F.N. 2023. Piper sarmentosum Roxb. methanolic extract prevents stress-induced gastric ulcer by modulating oxidative stress and inflammation. Front Pharmacol. 13:971443. 10.3389/fphar.2022.971443
Anisong N., Siripongvutikorn S., Puttarak P., and Wichienchot S. 2023. Fecal fermentation and gut microbiota modulation of dietary fibre and polyphenols from Gnetum gnemon Linn. leaves. Bioact Carbohydr Diet Fibre. 30:100380. 10.1016/j.bcdf.2023.100380
Anisong N., Siripongvutikorn S., Wichienchot S., and Puttarak P. 2022. A comprehensive review on nutritional contents and functional properties of Gnetum gnemon Linn. Food Sci Technol. 42:e100121. 10.1590/fst.100121
Anju T., Rai N.S.R., and Kumar A. 2022. Sauropus androgynus (L.) Merr.: a multipurpose plant with multiple uses in traditional ethnic culinary and ethnomedicinal preparations. J Ethnic Foods. 9:10. 10.1186/s42779-022-00125-8
Ashaduzzaman Nur M., Islam M., Biswas S., Hasan M.N., Rahman M.M., Uddin M.J., Satter M.A., and Amin M.Z. 2023. Determination of biological activities of malabar spinach (Basella alba) fruit extracts and molecular docking against COX-II enzyme. Heliyon. 9(11):e21568. 10.1016/j.heliyon.2023.e21568
Azelan A., Taher Z.M., Sasano S., Ariga T., and Aziz A.A. 2022. Chemical constituents and bioactivity of Piper sarmentosum: a mini review. Food Res. 4:14–18. 10.26656/fr.2017.4(S2).S10
Bamidele O., Arokoyo D.S., Akinnuga A.M., and Oluwarole A.O. 2015. Antidiabetic effect of aqueous extract of Basella alba leaves and metformin in alloxan-induced diabetic albino rats. Afr J Biotechnol. 13(24):2455–2458. 10.5897/AJB2014.13804
Bean A.R. 2007. A new system for determining which plant species are indigenous in Australia. Aust Syst Bot. 20(1):1–43. 10.1071/SB06030
Bose A., Banerjee S., Mandal S.K., Bose S., and Maity S. 2023. Comprehensive ethnomedicinal, pharmacological and phytochemical report on Basella alba L. (Basellaceae). J Nat Remed. 23(4):1–21.
Brewster L.M., Karamat F.A., and van Montfrans G.A. 2019. Creatine kinase and blood pressure: a systematic review. Med Sci. 7(4):58. 10.3390/medsci7040058
Buathong R., and Duangsrisai S. 2023. Plant ingredients in Thai food: a well-rounded diet for natural bioactive associated with medicinal properties. Peer J. 11:e14568. 10.7717/peerj.14568
Bunakkharasawat W., Panok L., and Panvisavas N. 2019. Genetic discrimination of the poisonous Urobotrya siamensis from the greenleaf vegetable ‘Pak-wan’. Forensic Sci Int Genet Supp Ser. 7(1):730–731. 10.1016/j.fsigss.2019.10.154
Bureau of nutrition. 2018. Food composition table of Thai foods. Department of Health, Ministry of public Health.
Cai X., Wang T., and Xie L. 2023. Lactate dehydrogenase is associated with flow-mediated dilation in hypertensive patients. Sci Rep. 13:768. 10.1038/s41598-023-27614-3
Chaing Mai University. 2022. FTI EXPO 2022. https://www.cmu.ac.th/th/article/0fd3c92f-86f4-4b3e-89ef-7828518783f1 (Accessed 20 April 2024).
Chanprapai P., and Chavasiri W. 2017. Antimicrobial activity from Piper sarmentosum Roxb. against rice pathogenic bacteria and fungi. J Integr Agric. 16(11):2513–2524. 10.1016/S2095-3119(17)61693-9
Chantan W., Kanchanarach W., Noppawan P., Khunwong C., Senakun C., Appamaraka S., Cumrae N., Udchachone S., Siriamornpun S., and Promprom W. 2023. Total phenolics, flavonoids contents and antioxidant activity in different flavor plants in northeast (Isaan) Thailand: enhancing commercial value. Trop J Nat Prod Res. 7(11):5115–5122.
Charoenchai F., Settharaksa S., Songsak T., Ruangrungsi N., and Kraisintu K. 2013. Phytochemical screening tests of Melientha suavis pierre and Urobotyra siamensis hiepko extracts. Bull Health Sci Technol. 11(2):13–20.
Chheang P., Hembry D.H., Yao G., and Luo S. 2022. Diversity and species-specificity of brood pollination of leafflower trees (Phyllanthaceae: Glochidion) by leafflower moths (Lepidoptera: Epicephala) in tropical Southeast Asia (Cambodia). Plant Divers. 44(2):191–200. 10.1016/j.pld.2021.07.001
Chumsri P., Panpipat W., Cheong L., Nisoa M., and Chaijan M. 2022. Comparative evaluation of hydrothermally produced rice starch–phenolic complexes: contributions of phenolic type, plasma-activated water, and ultrasonication. Foods. 11(23):3826. 10.3390/foods11233826
Cristina A.M., María José A., Beatriz S., Rosalba C., Beatriz P., Jaime G., Atiff R.C., Rafael H., Zafar H.I., Manuel V. 2007. Nitric oxide and malondialdehyde in human hypertension. Am J Therap. 14(2):172–176. 10.1097/01.pap.0000249914.75895.48
Dada A.O., Okareh O.T., Michael A., and Ogunyemi K.M. 2020. Protective effect of lyophilized aqueous extract of Basella alba vegetable on heamatological indices and selected organs of cyanide induced toxicity in rats. Int J Res Sci Innov. 7(5):66–72. https://EconPapers.repec.org/RePEc:bjc:journl:v:7:y:2020:i:5:p:66-72
Dedvisitsakul P., and Watla-Iad K. 2022. Antioxidant activity and antidiabetic activities of Northern Thai indigenous edible plant extracts and their phytochemical constituents. Heliyon. 8(9):e10740. 10.1016/j.heliyon.2022.e10740
Department of Intellectual Property, Ministry of Commerce, Thailand. 2024. https://search.ipthailand.go.th (Accessed 20 April 2024).
Deshmukh S.A., and Gaikwad D.K. 2014. A review of the taxonomy, ethnobotany, phytochemistry and pharmacology of Basella alba (Basellaceae). J Appl Pharm Sci. 4(1):153–165. 10.7324/JAPS.2014.40125
Dunkhunthod B., Talabnin C., Murphy M., Thumanu K., Sittisart P., and Eumkeb G. 2021. Gymnema inodorum (Lour.) Decne. extract alleviates oxidative stress and inflammatory mediators produced by raw264.7 macrophages. Oxid Med Cell Longev. 2021:8658314. 10.1155/2021/8658314
Ekpo F.E., Asuquo M.E., and Uwanta E.J. 2012. Comparative study of nutrient and anti-nutrientcontent of Gnetum africanum (afang) and Heinsia crinita (atama). Global J Pure Appl Sci. 18(1): 37–41.
Fadze N.F.M., Ugusman A., and Aminuddin A. 2018. Protective effect of Piper Sarmentosum against dexamethasone-induced hyperlipidemia in rats. Int J Cardiol. 273:20–21. 10.1016/j.ijcard.2018.11.080
Fauzy F.H., Zainudin M.M., Ismawi H.R., and Elshami T.F.T. 2019. Piper sarmentosum leaves aqueous extract attenuates vascular endothelial dysfunction in spontaneously hypertensive rats. Evid Based Complement Alternat Med. 2019:7198592. 10.1155/2019/7198592
Hsiue T., Guo Y.L., Chen K., Chen C., Lee C., and Chang H. 1998. Dose-response relationship and irreversible obstructive ventilatory defect in patients with consumption of Sauropus androgynus. CHEST. 113(1):71–76. 10.1378/chest.113.1.71
Islam S., Rahi S., Jahangir C.A., Rahman H., Jerin I., Amin R., Hoque K.F., and Reza A. 2018. In vivo anticancer activity of Basella alba leaf and seed extracts against Ehrlich’s ascites carcinoma (EAC) cell line. Evid Based Complement Alternat Med. 2018:1537896. 10.1155/2018/1537896
Jeytawan N., Yadoung S., Jeeno P., Yana P., Sutan K., Naksen W., Wongkaew M., Sommano S.R., and Hongsibsong S. 2022. Antioxidant and phytochemical potential and phytochemicals in Gymnema Inodorum (Lour.) Decne in Northern Thailand. Plants. 11(24):3498. 10.3390/plants11243498
Jiang D., and Wen X. 2021. Investigation on origin and development of epidemic disease. J. Liaoning Univ. Trad Chin Med. 23(2):1–4. 10.13194/j.issn.1673-842x.2021.02.001
Juajun O., Vanhanen L., Sangketkit C., and Savage G. 2012. Effect of cooking on the oxalate content of selected Thai vegetables. Food Nutr Sci. 3(12):1631–1635. 10.4236/fns.2012.312213.
Junsathian P., Nakamura S., Katayama S., and Rawdkuen 2022. Antioxidant and antimicrobial activities of Thai edible plant extracts prepared using different extraction techniques. Molecule. 27(19):6489. 10.3390/molecules27196489
Junsathian P., Yordtong K., Corpuz H.M., Katayama S., Nakamura S., and Rawdkuen S. 2018. Biological and neuroprotective activity of Thai edible plant extracts. Ind Crops Prod. 124(15):548–554. 10.1016/j.indcrop.2018.08.008
Karunasiri A.N., Gunawardane M., Senanayake C.M., Jayathilaka N., and Seneviratne K.N. 2020. Antioxidant and nutritional properties of domestic and commercial coconut milk preparations. Int J Food Sci. 2020(1):3489605. 10.1155/2020/3489605
Khoo H.E., Azlan A., and Ismail A. 2015. Sauropus androgynus leaves for health benefits: hype and the science. Nat Prod J. 5(2):115–123. 10.2174/221031550502150702142028
Kilari B., Netala V.R., Penchalaneni J., Kotakadi V.S., and Tartte V. 2018. Structural elucidation, in vitro cytotoxicity evaluation and mechansim study of newly secluded bioactive compound from the leaf extracts of Basella rubra L. Proc Biochem. 67:175–183. 10.1016/j.procbio.2018.02.002
Kleekayai T., Saetae D., Wattanachaiyingyong O., Tachibana S., Yasuda M., and Suntornsuk W. 2015. Characterization and in vitro biological activities of Thai traditional fermented shrimp pastes. J Food Sci Technol. 52(3):1839–1848. 10.1007/s13197-014-1528-y
Kongkachuichai R., Charoensiri R., Yakoh K., Kringkasemsee A., and Insung P. 2015. Nutrients value and antioxidant content of indigenous vegetables from Southern Thailand. Food Chem. 173:838–846. 10.1016/j.foodchem.2014.10.123.
Kozioł Ł., Knap M., Sutor-Świeży K., Górska R., Dziedzic E., Bieniasz M., Mielczarek P., Popenda Ł., Tyszka-Czochara M., and Wybraniec S. 2024. Identification and reactivity of pigments in prominent vegetable leaves of Basella alba L. var. ‘Rubra’ (Malabar spinach). Food Chem. 445(1):138714. 10.1016/j.foodchem.2024.138714
Kumar B.R., Anupam A., Manchikanti P., Rameshbabu A.P., Dasgupta S., and Dhara S. 2018. Identification and characterization of bioactive phenolic constituents, anti-proliferative, and anti-angiogenic activity of stem extracts of Basella alba and rubra. J Food Sci Technol. 55:1675–1684. 10.1007/s13197-018-3079-0
Kumar S.R., Ramli E.S.M., Nasir N.A.A., Ismail N.M., and Fahami N.A.M. 2021. Methanolic extract of Piper Sarmentosum attenuates obesity and hyperlipidemia in fructose-induced metabolic syndrome rats. Molecules. 26(13):3985. 10.3390/molecules26133985
Kumar S.S., Manoj P., and Giridhar P. 2015. Nutrition facts and functional attributes of foliage of Basella spp. Food Sci Technol (LWT). 64(1):468–474. 10.1016/j.lwt.2015.05.017
Kumar V., Bhat Z., Kumar D., Khan N.A., Chashoo I., and Ara I. 2012. Gastroprotective effect of leaf extracts of Basella alba against experimental gastric ulcers in rats. Rev Bras Farmacog. 22(3):657–662.
Lemmens R.H.M.J., and Wulijarni-Soetjipto N. 1991. Dye and tannin-producing plants. J Soc Dyers Colour. 107(11):414. 10.1111/j.1478-4408.1991.tb01289.x
Luangpirom A., Kourchampa W., and Somsapt P. 2014. Evaluation of hypoglycemic properties and fertility effect of Piper sarmentosum Roxb. Aqueous leaf extract in streptozotocin induced diabetic mice. Int J Phytomed. 6(3):448–454.
Maneenoon K., Khuniad C., Teanuan Y., Saedan N., Prom-in S., Rukleng N., Kongpool W., Pinsook P., and Wongwiwat W. 2015. Ethnomedicinal plants used by traditional healers in Phatthalung Province, Peninsular Thailand. J Ethnobio Ethnomed. 11:43. 10.1186/s13002-015-0031-5
Mathew S.P., Mohandas A., and Nair G.M. 2004. Piper sarmentosum Roxb.–an addition to the flora of Andaman Islands. Sci Correspond. 87(2):141–142.
Nambisan B. 2011. Strategies for elimination of cyanogens from cassava for reducing toxicity and improving food safety. Food Chem Toxicol. 49(3):690–693. 10.1016/j.fct.2010.10.035
Nanthapat S. 2010. พรรณพฤกษชาติในป่าโป่งสลอดจังหวัดเพชรบุร (Flora variety in Pa Pong Salot, Phetchaburi Province) 1st ed. Phetchaburi Rajabhat University, Thailand. Chamchuree products Co., LTD., Bangkok, Thailand.
Norkumai P., Wongkaew M., Tangpao T., Sritontip P., Wongsiri S., Junmahasathien T., Lumsangkul C., and Sommano S.R. 2023. Relationships between phenotypes and chemotypic characteristics of local gymnema inodorum plants in northern Thailand. Horticulturae. 9(4):484. 10.3390/horticulturae9040484
Othman N.S., Roos N.A.C., Aminuddin A., Murthy J.K., Hamid A.A., and Ugusman A. 2022. Effects of Piper sarmentosum Roxb. on hypertension and diabetes mellitus: a systematic review and meta-analysis. Front Pharmacol. 13:976247. 10.3389/fphar.2022.976247
Ou C., Chen C., Lee C., Lin C., Chang H., and Hsiue T. 2013. Pulmonary function change in patients with Sauropus androgynus-related obstructive lung disease 15 years later. J Formosan Med Assoc. 112(10):630–634. 10.1016/j.jfma.2012.07.042
Paseephol T., Ruksakhen Y., and Namhong S. 2012. Extraction of betalain from Ceylon spinach fruits. Agric Sci J. 43(3):368–371.
Paul M., and Anto K.B. 2011. Antibacterial activity of Sauropus androgynus (L.) Merr. Int J Plant Sci. 6(1):189–192.
Petroski W., and Minich D.M. 2020. Is there such a thing as “anti-nutrients”? A narrative review of perceived problematic plant compounds. Nutrients. 12(10): 2929. 10.3390/nu12102929
Phoraksa O., Chimkerd C., Thiyajai P., Judprasong K., Tuntipopipat S., Tencomnao T., Charoenkiatkul S., Muangnoi C., and Sukprasansap M. 2023. Neuroprotective effects of albizia lebbeck (l.) Benth. leaf extract against glutamate-induced endoplasmic reticulum stress and apoptosis in human microglial cells. Pharmaceuticals. 16(7):989. 10.3390/ph16070989
Punchay K., Inta A., Tiansawa P., Balslev H., and Wangpakapattanawon P. 2020. Nutrient and mineral compositions of wild leafy vegetables of the Karen and Lawa communities in Thailand. Foods. 9(12):1748. 10.3390/foods9121748
Purba R.A.P., and Paengkoum P. 2022. Exploring the phytochemical profiles and antioxidant, antidiabetic, and antihemolytic properties of Sauropus androgynus dried leaf extracts for ruminant health and production. Molecules. 27(23):8580. 10.3390/molecules27238580
Purba R.A.P., Paengkoum S., and Paengkoum P. 2021. Development of a simple high-performance liquid chromatography-based method to quantify synergistic compounds and their composition in dried leaf extracts of Piper Sarmentosum Roxb. Separations. 8(9):152. 10.3390/separations8090152
Syed Ab Rahman S.F., Sijam K., and Omar D. 2014. Chemical composition of Piper sarmentosum extracts and antibacterial activity against the plant pathogenic bacteria Pseudomonas fuscovaginae and Xanthomonas oryzae pv. oryzae. J Plant Dis Protec. 121(6):237–242. 10.1007/BF03356518
Ruttanaphan T., Thitathan W., Piyasaengthong N., Nobsathian S., and Bullangpoti V. 2022. Chrysoeriol isolated from Melientha suavis Pierre with activity against the agricultural pest Spodoptera litura. Chem Bio Technol Agric. 9:21. 10.1186/s40538-022-00287-2
Sakuljaitrong S., Buddhakala N., Buddhakala M., Asawawibul S., Buatone S., Tongaram Y., and Talubmook C. 2023. Phytochemicals, cytotoxicity, inhibitory effect on nitric oxideproduction and alpha-glucosidase activity, and dpph scavengingactivity of leaf extract from Gymnema inodorum (Lour.) Decne. Trends Sci. 20(5):6548. 10.48048/tis.2023.6548
Sallehuddin N.A., Abdul-Hamid A., Salleh S.Z., Abdul-Majid N., Halim H.H., Ramli N.S., Shukri R., Jaafar A.H., Hussin M., Anwar F., and Pak-Dek M.S. 2020. Ergogenic, anti-diabetic and antioxidant attributes of selected Malaysian herbs: characterisation of flavonoids and correlation of functional activities. Int Food Res J. 27(1):197–207.
Samtiya A., Aluko R.E., and Dhewa T. 2020. Plant food anti-nutritional factors and their reduction strategies: an overview. Food Prod Process Nutr. 2:6. 10.1186/s43014-020-0020-5
Samuhasaneeto S., Punsawad C., and Chaniad P. 2022. Protective effects of glochidion wallichianum mull. arg. on ethanol-induced liver injury in rats. Trends Sci. 19(12):4609. 10.48048/tis.2022.4609
Sandhya S., Chaintanya R.S.N.A.K.K., Vinod K.R., Rao K.N.V., Banji D., Sudhakar S., and Swetha R. 2010. An updated review on the genus Glochidion plant. Sch Res Lib. 2(2):309–322.
Sansomchai P., Jumpatong K., Lapinee C., and Utchariyajit K. 2021. Melientha suavis Pierre. extract: antioxidant and sunscreen properties for future cosmetic development. Chiang Mai University J Nat Sci. 20(1):e2021008.
Sheik A., Kim E., Adepelly U., Alhaammadi M., and Huh Y.S. 2023. Antioxidant and antiproliferative activity of Basella alba against colorectal cancer. Saudi J Bio Sci. 30(4):103609. 10.1016/j.sjbs.2023.103609
Singh V.P., Bali A., Singh N., and Jaggi A.S. 2014. Advanced glycation end products and diabetic complications. Korean J Physiol Pharmacol. 18(1):1–14. 10.4196/kjpp.2014.18.1.1
Sirichai P., Kittibunchakul S., Thangsiri S., On-Nom N., Chupeerach C., Temviriyanukul P., Inthachat W., Nuchuchua O., Aursalung A., Sahasakul Y., Charoenkiatkul S., and Suttisansanee. 2022. Impact of drying processes on phenolics and in vitro health-related activities of indigenous plants in Thailand. Plants. 11(3):294. 10.3390/plants11030294
Siripongvutikorn S., Banphot P., Rampoei N., and Thantrirat J. 2023a. Quality of Thai Furikake dried seasoning powder fortified with natural calcium and phosphorus. Italian J Food Sci. 35(4):88–111. 10.15586/ijfs.v35i4.2411
Siripongvutikorn S., Usawakesmanee W., Pisuchpen S., Khatcharin N., and Rujirapong C. 2023b. Nutritional content and microbial load of fresh liang, gnetum gnemon var. Tenerum leaves. Food. 12(20):3848. 10.3390/foods12203848
Sridonpai P., Kongprapun P., Sungayuth N., Sukprasansap M., Chimkerd C., and Judprasong K. 2022. Nutritive values and phytochemical compositions of edible indigenous plants in Thailand. Front Sustain Food Syst. 6:870147. 10.3389/fsufs.2022.870147
Srinuanchai W., Nooin R., Pitchakarn P., Karinchai J., Suttisansanee U., Chansriniyom C., Jarussophon S., Temviriyanukul P., and Nuchuchua O. 2021. Inhibitory effects of Gymnema inodorum (Lour.) Decne leaf extracts and its triterpene saponin on carbohydrate digestion and intestinal glucose absorption. J Ethnopharmacol. 266(10):113398. 10.1016/j.jep.2020.113398
Suksanga A., Siripongvutikorn S., Leelawattana R., Yupanqui C.T., and Idowu A. 2023. Assessment of biological activities, acute and sub-chronic toxicity of Liang (Gnetum gnemon var. tenerum) leaves powder, a natural product. Biol Pharm Bull. 46(12):1666–1675. 10.1248/bpb.b23-00208
Supattra L. 2022. Management to canopy of edible Monpu leaves. Thai Agric Res J. 18:7–12.
Surinkaew S., Sun D., Kooltheat N, Boonhok R., Somsak V., and Kumphune S. 2024. The cytoprotective effect of Gymnema inodorum leaf extract against hypoxia-induced cardiomyocytes injury. Heliyon. 10(15):e35846. 10.1016/j.heliyon.2024.e35846
Suttisansanee U., Thiyajai P., Inthachat W., Pruesapan K., Wongwathanarat K., Charoenkiatkul S., Sahasakul Y., and Temviriyanukul P. 2023. Exploration of the nutritional and carotenoids profiles of vegetables in Thai cuisine as potential nutritious ingredients. Heliyon. 9(5):e15951. 10.1016/j.heliyon.2023.e15951
Suzanne B.B.S., Mathieu N., Bertin S.E., Calvin M.J., Annie N.N.R., and G Clergé, T. 2017. Effects of cooking time on some antinutrients contents and in vitro digestibility of leaves proteins of Gnetum spp. Int J Nutr Food Sci. 6(2):99–104. 10.11648/j.ijnfs.20170602.16
Tangkanakul P., Trakoontivakorn G., Saengprakai J., Auttaviboonkul P., Niyomwit B., and Wongkrajang K. 2006. Antioxidant activity of northern and northeastern Thai foods containing indigenous vegetables. Agric Nat Res. 40(6):47–58. https://li01.tci-thaijo.org/index.php/anres/article/view/244014
Tangkanakul P., Trakoontivakorn G., Saengprakai J., Auttaviboonkul P., Niyomwit B., Lowvitoon N., and Nakahara K. 2011. Antioxidant capacity and antimutagenicity of thermal processed Thai foods. Japan Agric Res Quart. 45(2):211–218. 10.6090/jarq.45.211
Thailand Institute of Scientific and Technological Research. 2015. Melientha spicy curry. https://www.tistr.or.th/tistrblog/?p=2221 (Accessed 20 April 2024).
Thailand Techshow. 2024. Low sugar gymnema jelly gummy. https://thailandtechshow.com/view_techno.php?id=528 (Accessed 20 April 2024).
Thent Z.C., and Das S. 2015. Piper sarmentosum maintains blood pressure and morphological integrity of liver in type 1 diabetic rats. Int J Pharma Med Biol Sci. 4(1):24–28.
Thent ZC., Seong Lin, T., Das, S., and Zakaria, Z. 2012. Effect of Piper sarmentosum extract on the cardiovascular system of diabetic Sprague-Dawley rats: electron microscopic study. Evid Based Complement Altern Med. 2012:628750–628759.
Tiwari P., Mishra B.N., and Sangwan N.S. 2014. Phytochemical and pharmacological properties of Gymnema sylvestre: an important medicinal plant. BioMed Res Int. 2014:830285. 10.1155/2014/830285
Tongco J.V.V., Añis A.D., and Tamayo J.P. 2015. Nutritional analysis, phytochemical screening, and total phenolic content of Basella alba leaves from the Philippines. Int J Pharmacog Phytochem Res. 7(5):1031–1033.
Ugusman A., Zakaria Z., Hui C.K., Nordin N.A.M.M., and Mahdy Z.A. 2012. Flavonoids of Piper sarmentosum and its cytoprotective effects against oxidative stress. EXCLI J. 11:705–714.
Uhegbu F.O., Elekwa I., Iweala E.E.J., and Kanu I. 2011. Cyanide, nitrate and nitrite content of some leafy vegetables and fruits commonly consumed in the south-east of Nigeria. Pak J Nutr. 10(12):1190–1194. 10.3923/pjn.2011.1190.1194
Vega A., O’Brien J. A., and Gutierrez, R. A. 2019. Nitrate and hormonal signaling crosstalk for plant growth and development. Curr Opin Plant Biol. 52:155156. 10.1016/j.pbi.2019.10.001
Ware I., Franke K., Dube M., Enshasy H.A.E., and Wessjohann L.A. 2023. Characterization and bioactive potential of secondary metabolites isolated from Piper sarmentosum Roxb. J Mol Sci. 24(2):1328. 10.3390/ijms24021328
Wongnen C., Ruzzama N., Chaijan M., Cheong L., and Panpipat W. 2022. Glochidion wallichianum leaf extract as a natural antioxidant in sausage model system. Foods. 11(11):1547. 10.3390/foods11111547
Wongsa P., Chaiwarit J., and Zamaludien A. 2012. In vitro screening of phenolic compounds, potential inhibition against α-amylase and α-glucosidase of culinary herbs in Thailand. Food Chem. 131(3):964–971.
World Health Organization (WHO). 2011. Evaluation of certain food additives and contaminants. December 30, 2024. https://apps.who.int/food-additives-contaminants-jecfa-database/Home/Chemical/1086.
Xiong R., Zhou D., Wu S., Huang S., Saimaiti A., Yang Z., Shang A., Zhao C., Gan R., and Li H. 2022. Health benefits and side effects of short-chain fatty acids. Foods. 11(18):2863. 10.3390/foods11182863
Yoon A.S., and Sakdiset P. 2020. Development of microemulsions containing Gglochidion wallichianum leaf extract and potential for transdermal and topical skin delivery of gallic acid. Sci Pharm. 88(4):53. 10.3390/scipharm88040053
Zainudin M.M., Zakaria Z., and Megat Mohd Nordin N.A. 2015. The use of Piper sarmentosum leaves aqueous extract (Kadukmy™) as antihypertensive agent in spontaneous hypertensive rats. BMC Complement Altern Med. 15:54. 10.1186/s12906-015-0565-z
Zhu J., Song W., Li L., and Fan X. 2016. Endothelial nitric oxide synthase: a potential therapeutic target for cerebrovascular diseases. Mol Brain. 9:30. 10.1186/s13041-016-0211-9