Policaptil Gel Retard® reduces body weight and improves insulin sensitivity in obese subjects

Main Article Content

Giorgia Centorame
Maria Pompea Antonia Baldassarre
Giulia Di Dalmazi
Francesca Gambacorta
Fabrizio Febo
Agostino Consoli
Gloria Formoso


caloric intake, dietary fiber, glycemic index, Mediterranean diet, obesity


Policaptil Gel Retard® (PGR), a natural fiber-based molecule, has been shown to prevent weight gain and ameliorate insulin-resistance indices in obese children and adolescents. The aim of this study was to compare the effects of 12 weeks of low calories and low glycemic index (LC-LGI) diet associated or not with the intake of PGR on anthropometric, bioimpedance, and metabolic parameters. Data from 20 obese adult subjects (10 per group) were analyzed. An LC-LGI diet with or without PGR intake reduced weight, BMI, and waist circumference. PGR intake elicited a reduction in fasting plasma insulin and insulin resistance index together with an improvement in insulin sensitivity.

Abstract 61 | PDF Downloads 10 HTML Downloads 3 XML Downloads 1


Blüher, M., 2019. Obesity: global epidemiology and pathogenesis. Nature Reviews Endocrinology 15(5): 288–298. 10.1038/s41574-019-0176-8

Ceriello, A., 2003. New insights on oxidative stress and diabetic complications may lead to a “causal” antioxidant therapy. Diabetes Care 54(1), 1–7. 10.2337/diacare.26.5.1589

Dwyer, J.T., Melanson, K.J., Sriprachy-anunt, U., Cross, P. and Wilson, M., 2000. Dietary treatment of obesity. South Dart-mouth (MA). Endotext. MDText.com, Inc.

Esparza-Ros, F., Vaquero-Cristóbal, R. and Marfell-Jones, M., 2019. International standards for anthropometric assessment (2019). p. 115. Available at: https://www.researchgate.net/publication/236891109_International_Standards_for_Anthropometric_Assessment

Finer, N., 2015. Medical consequences of obesity. Medicine (United Kingdom) 43(2): 88–93. 10.1016/j.mpmed.2014.11.003

Fornari, E., Morandi, A., Piona, C., Tommasi, M., Corradi, M. and Maffeis, C., (2020). Policaptil gel retard intake reduces post-prandial triglycerides, ghrelin and appetite in obese children: a clinical trial. Nutrients 12(1): 214. 10.3390/nu12010214

Frühbeck, G., Toplak, H., Woodward, E., Yumuk, V., Maislos, M. and Oppert, J.M., 2013. Obesity: the gateway to ill health–an EASO position statement on a rising public health, clinical and scientific challenge in Europe. Obesity Facts 6(2): 117–120. 10.1159/000350627

Greco, C.M., Garetto, S., Montellier, E., Liu, Y., Chen, S., Baldi, P., Sassone-Corsi, P. and Lucci, J., 2020. A non-pharmacological therapeutic approach in the gut triggers distal metabolic rewiring capable of ameliorating diet-induced dysfunctions encompassed by metabolic syndrome. Scientific Reports 10(1): 12915. 10.1038/s41598-020-69469-y

Guarino, G., Della Corte, T., Strollo, F. and Gentile, S., 2021. Policaptil gel retard in adult subjects with the metabolic syndrome: efficacy, safety, and tolerability compared to metformin. Diabetes & Metabolic Syndrome 15(3): 901–907. 10.1016/J.DSX.2021.03.032

Katz, A., Nambi, S.S., Mather, K., Baron, A.D., Follmann, D.A., Sullivan, G. and Quon, M.J., 2000. Quantitative insulin sensitivity check index: a simple, accurate method for assessing insulin sensitivity in humans. The Journal of Clinical Endo-crinology & Metabolism 85(7): 2402–2410. 10.1210/jcem.85.7.6661

Laakso, M. and Kuusisto, J., 2014. Insulin resistance and hyper-glycaemia in cardiovascular disease development. Nature Reviews Endocrinology 10(5): 293–302. 10.1038/nrendo.2014.29

Matthews, D.R., Hosker, Rudenski, Naylor, Treacher, and Turner, 1985. Homeostasis model assessment: insulin resistance and β-cell function from fasting plasma glucose and insulin concentrations in man. Diabetologia 28(7): 412–419. 10.1007/BF00280883SINU, 2019.

Livelli Di Assunzione Di Riferimento Di Nutrienti Ed Energia per La Popolazione Italiana (LARN). Available at: https://sinu.it/larn/

Stagi, S., Lapi, E., Seminara, S., Pelosi, P., Del Greco, P., Capirchio, L., Strano, M., Giglio, S., Chiarelli, F. and De Martino, M., 2016. Policaptil gel retard® significantly lowered body mass index and hyperinsulinemia, and reduced the risk of diabetes mellitus type 2 (DM2) in children and adolescents with obesity, family history and DM2. Pediatriya 56(2): 38–45. 10.1186/s13052-015-0109-7

Stagi, S., Ricci, F., Bianconi, M., Sammarco, M.A., Municchi, G., Toni, S., Lenzi, L., Verrotti, A. and de Martino, M., 2017. Retrospective evaluation of metformin and/or metformin plus a new polysaccharide complex in treating severe hyperinsulinism and insulin resistance in obese children and adolescents with metabolic syndrome. Nutrients 9(5): 1–17. 10.3390/nu9050524

Weickert, M.O. and Pfeiffer, A.F.H., 2008. Metabolic effects of dietary fiber consumption and prevention of diabetes. Journal of Nutrition 138(3) 439–442. 10.1093/jn/138.3.439

WHO, 2015. Obesity: preventing and managing the global epidemic. WHO.